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Chemical Structure : A-745
Catalog No.: PC-72303Not For Human Use, Lab Use Only.
A-745 (A745) is a selective and potent HPK1 chemical probe (inhibitor) of HPK1 (MAP4K1) with IC50 of 4 nM.
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A-745 (A745) is a selective and potent HPK1 chemical probe (inhibitor) of HPK1 (MAP4K1) with IC50 of 4 nM.
A-745 demonstrates an excellent cellular selectivity binding profile within pharmacologically relevant concentrations in unbiased cellular kinase-binding assays.
A-745 exhibited in vitro immune cell activation phenotype reminiscent of Hpk1-deficient and Hpk1-kinase-dead T cells, including augmented proliferation and cytokine production.
A-745 is a selective and potent small molecule HPK1 inhibitors with the pharmacological properties for immunotherapy.
| M.Wt | 417.473 | |
| Formula | C22H23N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sven Malchow, et al. ACS Chem Biol. 2022 Feb 21.
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