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Chemical Structure : A-77636 hydrochloride
CAS No.: 145307-34-2
Catalog No.: PC-22227Not For Human Use, Lab Use Only.
A-77636 hydrochloride is a potent, selective, orally active and long acting dopamine D1 receptor agonist with Ki of 39.8 nM.
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A-77636 hydrochloride is a potent, selective, orally active and long acting dopamine D1 receptor agonist with Ki of 39.8 nM.
A-77636 is an agonist at the dopamine D1 receptors in the fish retina with EC50 of 1.1 nM.
A-77636 is functionally inactive at dopamine D2 receptors (EC50>10 uM).
A-77636 increases locomotor activity and decreases the severity of the parkinsonian-like symptoms in marmosets treated with MPTP to induce a parkinsonian-like state in rats and mice.
| M.Wt | 365.90 | |
| Formula | C20H28ClNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1R,3S)-3-(Adamantan-1-yl)-1-(aminomethyl)isochromane-5,6-diol hydrochloride |
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1. Acquas E, et al. Eur J Pharmacol. 1994 Jul 21;260(1):85-7.
2. Asin KE, et al. Brain Res. 1994 Feb 21;637(1-2):342-4.
3. Kebabian JW, et al. Eur J Pharmacol. 1992 Dec 15;229(2-3):203-9.
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