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Chemical Structure : A-966492
CAS No.: 934162-61-5
Catalog No.: PC-42678Not For Human Use, Lab Use Only.
A-966492 (A966492) is a highly potent and efficacious PARP inhibitor with Ki/EC50 of 1 nM/1 nM for PARP-1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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A-966492 (A966492) is a highly potent and efficacious PARP inhibitor with Ki/EC50 of 1 nM/1 nM for PARP-1, Ki of 1.5 nM for PARP-2.
A-966492 exhibits orally bioavailable across multiple species, crosses the blood-brain barrier, and appears to distribute into tumor tissue.
A-966492 demonstrates good in vivo efficacy in a B16F10 subcutaneous murine melanoma model.
| M.Wt | 324.3522 | |
| Formula | C18H17FN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1H-Benzimidazole-7-carboxamide, 2-[2-fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]- |
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1. Penning TD, et al. J Med Chem. 2010 Apr 22;53(8):3142-53.
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