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Chemical Structure : A-971432
Catalog No.: PC-20833Not For Human Use, Lab Use Only.
A-971432 is a potent, highly selective, CNS-penetrant and orally bioavailable agonist of S1P5 receptor with EC50 values of 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively.
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A-971432 is a potent, highly selective, CNS-penetrant and orally bioavailable agonist of S1P5 receptor with EC50 values of 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively.
A-971432 displays 60-fold selectivity over S1P1, and >1,600-fold selectivity over S1P2-4, and a panel of 129 kinases and 79 receptors.
A-971432 improves blood–brain barrier integrity in an in vitro model and reverses age-related cognitive decline in mice.
| M.Wt | 366.24 | |
| Formula | C18H17Cl2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hobson AD, et al. J Med Chem. 2015 Dec 10;58(23):9154-70.
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