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Chemical Structure : A4B17
Catalog No.: PC-73372Not For Human Use, Lab Use Only.
A4B17 is a small molecule that inhibits BAG1L-AR NTD interaction, inhibits the proliferation of AR positive prostate cancer cells.
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A4B17 is a small molecule that inhibits BAG1L-AR NTD interaction, inhibits the proliferation of AR positive prostate cancer cells.
A4B17 attenuates BAG1L-mediated AR NTD activity, downregulates AR target gene expression.
A4B17 attenuates the expression of AR target genes especially those that regulate oxidative stress and metabolism in a similar manner as a BAG1L knockout.
A4B17 functions more efficaciously than the clinically approved AR antagonist enzalutamide in enhancing the expression of a subset of genes distinct from androgen responsive-genes, a number of which are oxidative stress-induced genes involved in cell death.
A4B17 outperforms enzalutamide in a mouse xenograft model of prostate cancer under castration conditions.
| M.Wt | 297.271 | |
| Formula | C14H7F4NS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nane C Kuznik, et al. ACS Chem Biol. 2021 Nov 19;16(11):2103-2108.
2. Nane C. Kuznik, et al. et al. iScienceVol. 25Issue 5Published online: March 31, 2022
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