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Chemical Structure : A 83-01
CAS No.: 909910-43-6
Catalog No.: PC-42582Not For Human Use, Lab Use Only.
A 83-01 is a potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $178 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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A 83-01 is a potent, selective TGF-beta type I receptor ALK-5, ALK-4 and ALK-7 inhibitor with IC50 of 12, 45 and 7.5 nM, respectively.
A 83-01 dispalys weak or no inhibitory activity again transcriptional activity of ALK6 and ALK1/2/3.
A 83-01 prevents phosphorylation of Smad2/3 and the growth inhibition induced by TGF-beta with no effects on BMP signaling, ERK and p38 MAPK.
| M.Wt | 421.5168 | |
| Formula | C25H19N5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Pyrazole-1-carbothioamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)- |
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1. Tojo M, et al. Cancer Sci. 2005 Nov;96(11):791-800.
2. Yuan X, et al. Stem Cells. 2011 Mar;29(3):549-53.
3. Yamamura S, et al. Int J Cancer. 2012 Jan 1;130(1):20-8.
4. Minowa T, et al. Br J Cancer. 2009 Dec 1;101(11):1884-90.
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