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Chemical Structure : A83B4C63
Catalog No.: PC-73255Not For Human Use, Lab Use Only.
A83B4C63 is a potent small molecule DNA repair protein, polynucleotide kinase 3′-phosphatase (PNKP) inhibitor with Kd of 80 nM.
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A83B4C63 is a potent small molecule DNA repair protein, polynucleotide kinase 3'-phosphatase (PNKP) inhibitor with Kd of 80 nM.
A83B4C63 is a nano-encapsulated potent, but poorly water-soluble lead PNKP inhibitor with therapeutic potential for PTEN-deficient CRC.
Nano-carriers of A83B4C63 effectively inhibited the growth of HCT116/PTEN-/- xenografts in NIH-III nude mice following intravenous (IV) administration, but not that of wild-type HCT116/PTEN+/+ xenografts.
A83B4C63 encapsulated in NPs (NP/A83) based on mPEO-b-PBCL or solubilized with CE/A83, sensitized colorectal cancer cells to DNA damaging therapeutics in human HCT116 colorectal cancer (CRC) models.
| M.Wt | 564.598 | |
| Formula | C32H28N4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shire Z, et al. Mol Pharm. 2018 Jun 4;15(6):2316-2326.
2. Sadat SMA, et al. J Control Release. 2021 Jun 10;334:335-352.
3. Sadat SMA, et al. Front Oncol. 2021 Dec 23;11:772920.
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