Chemical Structure : AAP-SO2
CAS No.:
3033990-94-9
AAP-SO2
Catalog No.: PC-26173Not For Human Use, Lab Use Only.
AAP-SO2 is highly potent Mycobacterium tuberculosis (Mtb) RNA polymerase (RNAP) inhibitor with IC50 of 25 nM using an aptamer-based in vitro transcription assay, inhibits nucleotide addition, thereby reducing elongation and increasing termination rates.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AAP-SO2 is highly potent Mycobacterium tuberculosis (Mtb) RNA polymerase (RNAP) inhibitor with IC50 of 25 nM using an aptamer-based in vitro transcription assay, inhibits nucleotide addition, thereby reducing elongation and increasing termination rates.
AAP-SO2 directly bind Mtb RNAP and inhibits nucleotide addition.
AAP-SO2 shows increased activity against βS450L Mtb and slows the evolution of rifampicin resistance.
AAP-SO2 effectively kills replicating and non-replicating Mtb, kills non-replicating Mtb at a caseum minimal bactericidal concentration (casMBC90) of 7.89 μM.
Combination treatment with rifampicin and AAP-SO2 synergistically killed non-replicating Mtb in an ex vivo rabbit granuloma model.
Physicochemical Properties
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M.Wt
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495.57
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Formula
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C26H26FN3O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-N-(1-((2-(1,1-dioxidothiomorpholino)phenyl)amino)-1-oxo-3-phenylpropan-2-yl)-2-fluorobenzamide
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References
1. Bosch B, et al. Nat Microbiol. 2025 Dec 3. doi: 10.1038/s41564-025-02201-6.
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