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Chemical Structure : AB-423
CAS No.: 1572510-80-5
Catalog No.: PC-63323Not For Human Use, Lab Use Only.
AB-423 is a novel potent, class II HBV capsid inhibitor that shows potent inhibition of HBV replication with EC50 of 0.08-0.27 uM, with no significant cytotoxicity (CC50>10 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $285 | In stock | |
| 25 mg | $685 | In stock | |
| 100 mg | $1380 | In stock | |
| 250 mg | $2380 | In stock | |
| 1 g | Get quote |
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AB-423 is a novel potent, class II HBV capsid inhibitor that shows potent inhibition of HBV replication with EC50 of 0.08-0.27 uM, with no significant cytotoxicity (CC50>10 uM); inhibits HBV genotypes A through D and nucleos/tide-resistant variants, causes capsid particles devoid of encapsidated pgRNA and rcDNA in treated HepDES19 cells, prevents the conversion of encapsidated rcDNA to cccDNA presumably by interfering with the capsid uncoating process; dose-dependently reduces serum HBV DNA levels in mouse model of HBV model, shows synergistic antiviral activity combined with entecavir (ETV).
HBV Infection
Phase 1 Clinical
| M.Wt | 386.389 | |
| Formula | C17H17F3N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-5-(N-(sec-butyl)sulfamoyl)-N-(3,4-difluorophenyl)-2-fluorobenzamide |
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1. Mani N, et al. Antimicrob Agents Chemother. 2018 Mar 19. pii: AAC.00082-18.
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