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Chemical Structure : AB1
Catalog No.: PC-60746Not For Human Use, Lab Use Only.
AB1 is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 3 nM, with no agonistic or antagonistic activities on other S1PRs.
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AB1 is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 3 nM, with no agonistic or antagonistic activities on other S1PRs.
AB1 is more effective than JTE-013 in blocking S1P2-mediated inhibition of cell migration in nuroblastoma, inhibits (C-C motif) ligand 2 expression and significantly inhibits subsequent tumor-associated macrophage infiltration in neuroblastoma xenografts.
AB1 induces apoptosis and shows antitumor activity in neuroblastoma models.
| M.Wt | 434.325 | |
| Formula | C19H21Cl2N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li MH, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):261-8.
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