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AB1

Chemical Structure : AB1

CAS No.: 1463912-49-3

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AB1 (AB-1， AB 1)

Catalog No.: PC-60746Not For Human Use, Lab Use Only.

AB1 is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 3 nM, with no agonistic or antagonistic activities on other S1PRs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AB1 is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 3 nM, with no agonistic or antagonistic activities on other S1PRs.
    AB1 is more effective than JTE-013 in blocking S1P2-mediated inhibition of cell migration in nuroblastoma, inhibits (C-C motif) ligand 2 expression and significantly inhibits subsequent tumor-associated macrophage infiltration in neuroblastoma xenografts.
    AB1 induces apoptosis and shows antitumor activity in neuroblastoma models.

    Physicochemical Properties

    M.Wt 434.325
    Formula C19H21Cl2N7O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(1H-4-isopropyl-1-allyl-3-methylpyrazolo[3,4-b]pyridine-6-yl)-amino-N'-(2,6-dichloropyridine-4-yl) urea

    References

    1. Li MH, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):261-8.

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