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Chemical Structure : ABBV-105
Catalog No.: PC-35203Not For Human Use, Lab Use Only.
ABBV-105 (ABBV105) is a potent, selective, irreversible, covalent inhibitor of BTK with IC50 of 0.18 uM.
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ABBV-105 (Elsubrutinib, ABBV105) is a potent, selective, irreversible, covalent inhibitor of BTK with IC50 of 0.18 uM.
ABBV-105 irreversibly inhibits BTK, demonstrating superior kinome selectivity and is potent in B cell receptor, Fc receptor, and TLR-9-dependent cellular assays.
ABBV-105 inhibits antibody responses to thymus-independent and thymus-dependent antigens, paw swelling and bone destruction in rat collagen induced arthritis (CIA), and reduces disease in an IFNα-accelerated lupus nephritis model.
| M.Wt | 297.36 | |
| Formula | C17H19N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Goess C, et al. Mod Rheumatol. 2018 Jun 2:1-32. doi: 10.1080/14397595.2018.1484269.
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