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Chemical Structure : ABT-100
Catalog No.: PC-35110Not For Human Use, Lab Use Only.
ABT-100 (ABT100) is a highly selective, potent, orally bioavailable inhibitor of farnesyltransferase (FTase).
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ABT-100 (ABT100) is a highly selective, potent, orally bioavailable inhibitor of farnesyltransferase (FTase).
ABT-100 inhibits proliferation of cells in vitro carrying oncogenic H-Ras (EJ-1 bladder, IC50=2.2 nM), K-Ras (DLD-1 colon, MDA-MB-231 breast, HCT-116 colon, and MiaPaCa-2 pancreatic, IC50=3.8-9.2 nM), and wild-type Ras (PC-3 and DU-145, IC50=70 and 818 nM).
ABT-100 inhibits in vivo growth of a series of xenografts.
| M.Wt | 504.46 | |
| Formula | C27H19F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ferguson D, et al. Clin Cancer Res. 2005 Apr 15;11(8):3045-54.
2. Carloni V, et al. Clin Cancer Res. 2005 Jun 1;11(11):4266-74.
3. Gu WZ, et al. Anticancer Drugs. 2005 Nov;16(10):1059-69.
4. Fong LG, et al. Science. 2006 Mar 17;311(5767):1621-3.
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