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Chemical Structure : ABT-546
Catalog No.: PC-20050Not For Human Use, Lab Use Only.
ABT-546 (A-216546) is a potent, selective, small-molecule antagonist of ETA endothelin receptor with IC50 of 0.49 nM, shows high selectivity over ETB receptor.
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ABT-546 (A-216546) is a potent, selective, small-molecule antagonist of ETA endothelin receptor with IC50 of 0.49 nM, shows high selectivity over ETB receptor.
ABT-546 effectively inhibits specific I endothelin-1 binding to endothelin ETA receptor in membrane prepared from rat pituitary MMQ cells with IC50 of 0.56 nM.
ABT-546 blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC50 of 0.59 nM and 3 nM, respectively.
| M.Wt | 532.72 | |
| Formula | C30H48N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wessale JL, et al. Clin Sci (Lond). 2002 Aug;103 Suppl 48:112S-117S.
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