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Chemical Structure : ABT-639
CAS No.: 1235560-28-7
Catalog No.: PC-45686Not For Human Use, Lab Use Only.
ABT-639 is a novel, peripherally acting, selective T-type calcium channel blocker, blocks recombinant human Cav 3.2 in a voltage-dependent fashion (IC50=2 uM).
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|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
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| 100 mg | Get quote |
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ABT-639 is a novel, peripherally acting, selective T-type calcium channel blocker, blocks recombinant human Cav 3.2 in a voltage-dependent fashion (IC50=2 uM).
ABT-639 attenuates LVA currents in rat DRG neurons (IC50=8 uM).
ABT-639 is less active at other Ca2+ channels (IC50> 30 uM).
ABT-639 effectively reduces nociceptive and neuropathic pain in rats; high oral bioavailability.
| M.Wt | 455.9059 | |
| Formula | C20H20ClF2N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mg/mL |
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| Chemical Name/SMILES |
Benzenesulfonamide, 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]- |
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1. Jarvis MF, et al. Biochem Pharmacol. 2014 Jun 15;89(4):536-44.
2. Teleb M, et al. Bioorg Med Chem. 2017 Mar 15;25(6):1926-1938.
3. Serra J, et al. Pain. 2015 Nov;156(11):2175-83.
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