Catalog No.: PC-45686Not For Human Use, Lab Use Only.
ABT-639 is a novel, peripherally acting, selective T-type calcium channel blocker, blocks recombinant human Cav 3.2 in a voltage-dependent fashion (IC50=2 uM).
ABT-639 is a novel, peripherally acting, selective T-type calcium channel blocker, blocks recombinant human Cav 3.2 in a voltage-dependent fashion (IC50=2 uM).
ABT-639 attenuates LVA currents in rat DRG neurons (IC50=8 uM).
ABT-639 is less active at other Ca2+ channels (IC50> 30 uM).
ABT-639 effectively reduces nociceptive and neuropathic pain in rats; high oral bioavailability.
