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Chemical Structure : AC1903
CAS No.: 831234-13-0
Catalog No.: PC-60025Not For Human Use, Lab Use Only.
AC1903 is a potent, specific TRPC5 channel inhibitor with IC50 of 14.7 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $218 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | $598 | In stock | |
| 500 mg | $958 | In stock | |
| 1 g | Get quote |
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AC1903 is a potent, specific TRPC5 channel inhibitor with IC50 of 14.7 uM.
AC1903 blocks riluzole-activated TRPC5 whole-cell current, but fails to block carbachol (CCh)-induced TRPC4 and OAG-induced TRPC6 currents, even at high micromolar concentrations.
AC1903 pecifically blocks TRPC5 channel activity in glomeruli of proteinuric rats, suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of FSGS.
| M.Wt | 303.365 | |
| Formula | C19H17N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO (30.3 mg/mL) |
|
| Chemical Name/SMILES |
1-benzyl-N-(furan-2-ylmethyl)-1H-benzo[d]imidazol-2-amine |
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1. Zhou Y, et al. Science. 2017 Dec 8;358(6368):1332-1336.
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