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Chemical Structure : ACA-14
Catalog No.: PC-20692Not For Human Use, Lab Use Only.
ACA-14 is a small molecule direct inhibitor of KRAS, impedes the interaction of KRAS with its effector Raf and reduces both intrinsic and SOS-mediated nucleotide exchange rates.
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ACA-14 is a small molecule direct inhibitor of KRAS, impedes the interaction of KRAS with its effector Raf and reduces both intrinsic and SOS-mediated nucleotide exchange rates.
ACA-14 inhibits signal transduction through the MAPK pathway in cells expressing mutant KRAS and inhibits the growth of pancreatic and colon cancer cells harboring mutant KRAS.
| M.Wt | 297.31 | |
| Formula | C17H15NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cynthia V Pagba, et al. ACS Bio Med Chem Au. 2022 Sep 26;2(6):617-626.
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