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ACHN-975

Chemical Structure : ACHN-975

CAS No.: 1410809-36-7

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ACHN-975 (ACHN975)

Catalog No.: PC-38311Not For Human Use, Lab Use Only.

ACHN-975 (ACHN975) is a potent bacterial LpxC inhibitor with IC50 of 0.68 nM (P. aeruginosa LpxC).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ACHN-975 (ACHN975) is a potent bacterial LpxC inhibitor with IC50 of 0.68 nM (P. aeruginosa LpxC).
    ACHN-975 is potent against the P. aeruginosa isolates with MIC50 of 0.06 ug/mL and MIC90 of 0.25 ug/mL.
    ACHN-975 demonstrated effectivity in a neutropenic mouse thigh model with P. aeruginosa ATCC 27853.

    Physicochemical Properties

    M.Wt 369.421
    Formula C20H23N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diyn-1-yl)benzamide

    References

    1. Cohen F, et al. ChemMedChem. 2019 Aug 20;14(16):1560-1572.

    2. Krause KM, et al. Antimicrob Agents Chemother. 2019 Oct 22;63(11):e00977-19. 

    3. Fan S, et al. Molecules. 2021 Mar 7;26(5):1451.

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