ACP1-06 | ClpP activator | Probechem Biochemicals

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Chemical Structure : ACP1-06

ACP1-06 (ACP1b)

Catalog No.: PC-25351Not For Human Use, Lab Use Only.

ACP1-06 (ACP1b) is a small molecule activator of bacterial ClpP with EC50 of 0.3 μM and 0.7 μM for NmClpP and EcClpP respectively, binds to ClpP H sites and activates the protease, shows antibacterial activity by virtue of the ability to dysregulate the cylindrical protease.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	466.92
Formula	C18H18ClF3N2O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((2-chlorophenyl)thio)ethyl)-2-methyl-2-((5-(trifluoromethyl)pyridin-2-yl)sulfonyl)propanamide

References

1. Barghash MM, et al. Structure. 2025 Aug 5:S0969-2126(25)00261-8.

3. Leung E, et al. Chem Biol. 2011 Sep 23;18(9):1167-78.

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ACP1-06 (ACP1b)

Biological Activity

Physicochemical Properties

References

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