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Chemical Structure : ACT-1004-1239
Catalog No.: PC-72634Not For Human Use, Lab Use Only.
ACT-1004-1239 is a potent, selective, orally available CXCR7 antagonist with IC50 of 3.2 nM (hCXCR7).
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ACT-1004-1239 is a potent, selective, orally available CXCR7 antagonist with IC50 of 3.2 nM (hCXCR7).
ACT-1004-1239 also shows similar potency against rat, mouse and dog CXCR (IC50=2-3 nM), shows high selectivity in a panel of 87 enzymatic and radioligand binding assays (CXCR4, IC50>10 uM).
ACT-1004-1239 is a potent insurmountable CXCR7 antagonist against both CXCL11 and CXCL12, shows a dose-dependent increase of CXCL12 plasma concentration in mice.
| M.Wt | 522.557 | |
| Formula | C27H28F2N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sylvia Richard-Bildstein, et al. J Med Chem. 2020 Dec 24;63(24):15864-15882.
2. Huynh C, et al. Clin Pharmacol Ther. 2021 Jun;109(6):1648-1659.
3. Huynh C, et al. Biomed Pharmacother. 2021 Dec;144:112363.
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