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Chemical Structure : AD 2900
Catalog No.: PC-60340Not For Human Use, Lab Use Only.
AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively.
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AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively.
AD 2900 shows no significant agonism effects (EC50>50 uM); suppresses PBMC proliferation, regulates the expression of S1P1 and CCR7 on PBMCs.
AD 2900 accumulates T cells in the blood and spleen and in turn reduces T-cell number in the lymph nodes.
AD 2900 shows significant effects on the localization of T-cell subpopulations in mic.
| M.Wt | 345.568 | |
| Formula | C20H43NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Song J, et al. Oncotarget. 2017 Jun 27;8(32):53563-53580.
2. Dagan A, et al. Biochim Biophys Acta. 2003 Sep 22;1633(3):161-9.
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