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Chemical Structure : AD80
CAS No.: 1384071-99-1
Catalog No.: PC-35268Not For Human Use, Lab Use Only.
AD80 is a multikinase inhibitor that shows strong activity against human RET (IC50=4 nM), BRAF, S6K, and SRC, but has greatly reduced mTOR activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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AD80 is a multikinase inhibitor that shows strong activity against human RET (IC50=4 nM), BRAF, S6K, and SRC, but has greatly reduced mTOR activity.
AD80 inhibits S6K1 and suppress oncogenic function downstream of a transforming mutant of the receptor tyrosine kinase Ret.
AD80 demonstrates selective cytotoxicity for PTEN-deficient cells established S6K1 as part of a kinase targeting portfolio for in vitro and in vivo cytotoxic therapy of PTEN-deficient cancers.
AD80 inhibits proliferation of MZ-CRC-1 and TT thyroid cancer cells in culture, also promotes enhanced tumour growth inhibition and reduced body-weight modulation relative to vandetanib in a mouse xenograft model.
| M.Wt | 473.436 | |
| Formula | C22H19F4N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[4-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea |
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1. Plenker D, et al. Sci Transl Med. 2017 Jun 14;9(394). pii: eaah6144.
2. Liu H, et al. Cell Rep. 2017 Feb 28;18(9):2088-2095.
3. Dar AC, et al. Nature. 2012 Jun 6;486(7401):80-4.
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