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Chemical Structure : ADAM17 inhibitor SN-4
Catalog No.: PC-72743Not For Human Use, Lab Use Only.
ADAM17 inhibitor SN-4 is a novel specific inhibitor of A disintegrin and metalloproteinase 17 (ADAM17), inhibits TNF-α cleavage by SN-4 in cells with IC50 of 3.22 uM.
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ADAM17 inhibitor SN-4 is a novel specific inhibitor of A disintegrin and metalloproteinase 17 (ADAM17), inhibits TNF-α cleavage by SN-4 in cells with IC50 of 3.22 uM.
SN-4 showed slightly higher activity than the well-studied ADAM17 inhibitor marimastat.
SN-4 inhibited the ability of ADAM17 to cleave tumor necrosis factor α (TNF-α) in vitro, inhibited cleavage of CD44 by ADAM17, but not by ADAM10, and to suppress cell invasion.
| M.Wt | 508.714 | |
| Formula | C23H32N4O3S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hiroshi Tateishi, et al. Chem Pharm Bull (Tokyo). 2021;69(11):1123-1130.
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