ADAMTS7 inhibitor 50

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Chemical Structure : ADAMTS7 inhibitor 50

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Catalog No.: PC-21754Not For Human Use, Lab Use Only.

ADAMTS7 inhibitor 50 is a potent selective ADAMTS7 inhibitor with IC50 of 2 nM, 20-fold selective over ADAMTS12 and highly selective over a range of metalloproteases.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ADAMTS7 inhibitor 50 is a potent selective ADAMTS7 inhibitor with IC50 of 2 nM, 20-fold selective over ADAMTS12 and highly selective over a range of metalloproteases.

Physicochemical Properties

M.Wt	569.49
Formula	C28H20F5N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5,6-difluoro-N-((4-(1-methyl-3-phenyl-1H-pyrazol-5-yl)-2,5-dioxoimidazolidin-4-yl)methyl)-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamide

References

1. Meibom D, et al. J Med Chem. 2024 Feb 13. doi: 10.1021/acs.jmedchem.3c02036.

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