Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : ADT-007
Catalog No.: PC-21775Not For Human Use, Lab Use Only.
ADT-007 (ADT007) is a potent, specific pan-RAS inhibitor, shows potential to circumvent resistance to mutant-specific KRAS inhibitors and activates antitumor immunity.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
ADT-007 (ADT007) is a potent, specific pan-RAS inhibitor, shows potential to circumvent resistance to mutant-specific KRAS inhibitors and activates antitumor immunity.
ADT-007 displays high potency and selectivity to inhibit the growth of KRAS G13D HCT-116 cells with an IC50 of 5 nM, 100 fold less sensitive to RAS WT HT-29 cells.
ADT-007 displays potency in KRAS G12C MIA PaCa-2 PDA cells, resulting in IC50 values as low as 2 nM and a selectivity index approaching 1200-fold relative to RAS WT BxPC-3 PDA cells.
ADT-007 also potently inhibits the growth of three other mutant KRAS PDA cell lines with G12V or G12D mutations.
ADT-007 suppresses MIA PaCa-2 cells growth in 2D monolayer and 3D spheroid cultures with IC50 values of 2.1 and 3.3 nM, respectively.
ADT-007 completely inhibits colony formation of PDA cell lines with G12C, G12D, and G12V KRAS mutations, whereas colony formation of RASWT 136 BxPC-3 cells is not significantly affected.
ADT-007 inhibits activated RAS and downstream MAPK/AKT signaling in human CRC and PDA cell lines.
ADT-007 exhibited 10x greater potency than AMG-510 in growth assays involving parental mutant KRAS G12C MIA PaCa-2 cells, also potently inhibits Lewis lung cancer (LLC) cells (NRAS Q61H) growth with IC50 of 9 nM.
ADT-007 preferentially binds nucleotide-free RAS, inhibit RAS-driven cancer cell growth, activated RAS levels, and MAPK/AKT signaling.
| M.Wt | 449.48 | |
| Formula | C26H24FNO5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Jeremy B Foote, et al. bioRxiv. 2024 Jan 24:2023.05.17.541233.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
