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Chemical Structure : ADX-47273
CAS No.: 851881-60-2
Catalog No.: PC-43360Not For Human Use, Lab Use Only.
ADX-47273 is a potent and selective mGlu5 positive allosteric modulators (PAM) with with EC50 of 170 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | $428 | In stock | |
| 500 mg | Get quote |
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ADX-47273 is a potent and selective mGlu5 positive allosteric modulators (PAM) with with EC50 of 170 nM; causes a concentration-dependent increase in the response to 300 nM glutamate in primary astrocyte cultures with EC50 of 230 nM; displays no agonist, antagonist, or allosteric responses against rat mGlu1, human mGlu2 and mGlu4; increases ERK and CREBP phosphorylation in hippocampus and prefrontal cortex, demonstrates antipsychotic-like and procognitive activities in vivo models.
| M.Wt | 369.3647 | |
| Formula | C20H17F2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Methanone, (4-fluorophenyl)[(3S)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]- |
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1. de Paulis T, et al. J Med Chem. 2006 Jun 1;49(11):3332-44.
2. Liu F, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):827-39.
3. Engers DW, et al. ChemMedChem. 2009 Apr;4(4):505-11.
4. Rosenbrock H, et al. Eur J Pharmacol. 2010 Aug 10;639(1-3):40-6.
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