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Chemical Structure : AE-848
Catalog No.: PC-21362Not For Human Use, Lab Use Only.
AE-848 is a small molecule modulator of NF-κB and PI3K/AKT/mTOR signaling pathways, shows potent in vitro and in vivo anti-myeloma activity.
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AE-848 is a small molecule modulator of NF-κB and PI3K/AKT/mTOR signaling pathways, shows potent in vitro and in vivo anti-myeloma activity.
AE-848 (5 µM, 24 and 48 h) significantly induces apoptosis of U266 and RPMI8226 cells, markedly induces loss of MMP.
AE-848 induces cleavage of caspase-8, caspase-3, and PARP, induces apoptosis in a caspase-dependent manner and inhibits the NF-κB and PI3K/Akt/mTOR signaling pathways.
AE-848 (12.5 mg/kg, i.p.) significantly inhibits tumor growth and prolongs overall survival of MM cell-bearing mice.
| M.Wt | 517.39 | |
| Formula | C24H21BrN8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xu Y, et al. Onco Targets Ther. 2020 Dec 22;13:13063-13075.
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