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Chemical Structure : AES-135
CAS No.: 2361659-61-0
Catalog No.: PC-72098Not For Human Use, Lab Use Only.
AES-135 (AES135) is a novel small molecule HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 with IC50 of 654, 190, 636 nM, with low-uM activity against HDAC8 (IC50=1.2 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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AES-135 (AES135) is a novel small molecule HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 with IC50 of 654, 190, 636 nM, with low-uM activity against HDAC8 (IC50=1.2 uM).
AES-135 exhibits selective in vitro cytotoxicity (IC50=1-4 uM) in low-passage patient-derived pancreatic cancer cells even in the presence of cancer-associated fibroblast (CAF) cells.
AES-135 has favorable in vivo properties such as metabolic stability in mouse hepatocytes and bioavailability in micromolar (μM) concentrations in NSG mice for >10 h (IP injection).
AES-135 increased survival of C57Bl/6 mice implanted with KPC tumor cells in vivo.
| M.Wt | 693.661 | |
| Formula | C33H29F6N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy- |
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1. Shouksmith AE, et al. J Med Chem. 2019 Mar 14;62(5):2651-2665.
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