Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AG-1031
Catalog No.: PC-20734Not For Human Use, Lab Use Only.
AG-1031 (AG1031) is a specific small molecule inhibitor of the double-stranded DNA binding activity of positive coactivator 4 (PC4) with IC50 of 2.5 uM, more effectively than its single-stranded DNA binding activity (IC50=15 uM).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AG-1031 (AG1031) is a specific small molecule inhibitor of the double-stranded DNA binding activity of positive coactivator 4 (PC4) with IC50 of 2.5 uM, more effectively than its single-stranded DNA binding activity (IC50=15 uM).
AG-1031 specifically inhibited PC4-dependent transcriptional activation in vitro using purified transcription factors.
AG-1031 also interfered with PC4 binding to a monoclonal antibody against PC4 and with PC4 binding to the transcription activator VP16.
AG-1031 (0.3 μM, 72 h) inhibited the viability of lung adenocarcinoma cell line A549 cells, significantly reduced the expression of PC4.
AG-1031 (40 μg/mouse) inhibited tumor growth in A549 cell xenografts, with reduced level of PC4 protein.
AG-1031 induced autophagic cell death and apoptosis in C6 glioma cells associated with Notch-1 signaling pathway.
| M.Wt | 718.8 | |
| Formula | C41H42N4O8 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Wang Y, et al. J Cell Biochem. 2018 Jul;119(7):5893-5903.
2. Zhang Y,et al. PLoS One. 2020 Mar 31;15(3):e0230670.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
