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AG-120-X

Chemical Structure : AG-120-X

CAS No.: 1376918-61-4

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AG-120-X

Catalog No.: PC-21199Not For Human Use, Lab Use Only.

AG-120-X is a first-in-class small molecule inhibitor of ICOS/ICOSL interaction with IC50 of 4.68 uM in TR-FRET assay, dose-dependently blocks ICOS/ICOSL interaction in cellular assay based on co-culturing Jurkat T cells expressing ICOS and CHO-K1 cells expressing ICOSL.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AG-120-X is a first-in-class small molecule inhibitor of ICOS/ICOSL interaction with IC50 of 4.68 uM in TR-FRET assay, dose-dependently blocks ICOS/ICOSL interaction in cellular assay based on co-culturing Jurkat T cells expressing ICOS and CHO-K1 cells expressing ICOSL.

    Physicochemical Properties

    M.Wt 427.89
    Formula C24H18ClN5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-(benzylamino)-6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide

    References

    1. Abdel-Rahman SA, et al. RSC Med Chem. 2023 Aug 1;14(9):1767-1777.

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