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Chemical Structure : AG-205
Catalog No.: PC-70186Not For Human Use, Lab Use Only.
A small molecule inhibitor of progesterone receptor membrane component 1 (PGRMC1) that alters the spectroscopic properties of the PGRMC1-heme complex.
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A small molecule inhibitor of progesterone receptor membrane component 1 (PGRMC1) that alters the spectroscopic properties of the PGRMC1-heme complex; decreases GLP-1-induced insulin secretion in β cells; inhibits cancer cell viability and cancer cell progression, acting preferentially on PGRMC1-expressing cells.
| M.Wt | 454.98 | |
| Formula | C22H23ClN6OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Privett BR, et al. Biochemistry. 2017 Jul 25;56(29):3840-3849.
2. Zhang M, et al. Mol Cell Proteomics. 2014 Nov;13(11):3049-62.
3. Mir SU, et al. Int J Cancer. 2012 Jul 15;131(2):E1-9.
4. Terzaghi L, et al. Cell Cycle. 2016 Aug 2;15(15):2019-32.
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