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Chemical Structure : AG1024
CAS No.: 65678-07-1
Catalog No.: PC-42488Not For Human Use, Lab Use Only.
A specific IGF-1R inhibitor that inhibits IGF-1R autophosphorylation with IC50 of 7 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $95 | In stock | |
| 50 mg | $285 | In stock | |
| 250 mg | Get quote |
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A specific IGF-1R inhibitor that inhibits IGF-1R autophosphorylation with IC50 of 7 uM; weakly blocks IR autophosphorylation with IC50 of 57 uM; also inhibits the receptor tyrosine kinase activity towards exogenous substrates (TKA) with IC50 of 18 μuM and 80 uM, respectively; down-regulates expression of Bcr-Abl and P-Akt, and up-regulates DNA-PKcs expression in UT7-9 and Ba/F3-p210 cells.
| M.Wt | 305.1698 | |
| Formula | C14H13BrN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Propanedinitrile, 2-[[3-bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]- |
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1. Párrizas M, et al. Endocrinology. 1997 Apr;138(4):1427-33.
2. Wen B, et al. Br J Cancer. 2001 Dec 14;85(12):2017-21.
3. von Willebrand M, et al. Cancer Res, 2003, 63(6), 1420-1429.
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