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Chemical Structure : AGI-14100
Catalog No.: PC-35206Not For Human Use, Lab Use Only.
AGI-14100 (AGI14100) is a novel potent and selective, orally available IDH1 mutant inhibitor, inhibits cell proliferation (human cell lines transfected with IDH1 R132H) with IC50 values of 0.76 nM (HT-1080), 0.74 nM (U87-MG) and 1.75 nM (TF1).
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AGI-14100 (AGI14100) is a novel potent and selective, orally available IDH1 mutant inhibitor, inhibits cell proliferation (human cell lines transfected with IDH1 R132H) with IC50 values of 0.76 nM (HT-1080), 0.74 nM (U87-MG) and 1.75 nM (TF1).
AGI-14100 can specifically induce cellular differentiation in AML patient samples with mutant IDH1 ex vivo.
AGI-14100 significantly reduces the leukemic blast burden in the peripheral blood in xenograft model with a primary human IDH1 R132H/FLT3-ITD tumor.
| M.Wt | 599.971 | |
| Formula | C29H22ClF4N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ma T, et al. J Med Chem. 2018 Jun 18. doi: 10.1021/acs.jmedchem.8b00159.
2. Kate Ellwood-Yen, et al. Abstract 1194: IDH1 mutant inhibitor induces cellular differentiation and offers a combination benefit with Ara-C in a primary human Idh1 mutant AML xenograft model. AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA.
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