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Chemical Structure : AGI-5198
CAS No.: 1355326-35-0
Catalog No.: PC-45413Not For Human Use, Lab Use Only.
AGI-5198 (IDH-C35) is a potent, selective mutant IDH1 inhibitor with IC50 of 70 nM and 160 nM for R132H-IDH1 and R132C-IDH1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 50 mg | $98 | In stock | |
| 100 mg | $148 | In stock | |
| 250 mg | Get quote |
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AGI-5198 (IDH-C35) is a potent, selective mutant IDH1 inhibitor with IC50 of 70 nM and 160 nM for R132H-IDH1 and R132C-IDH1, respectively.
AGI-5198 shows no inhibitory activity for wild type IDH1, IDH2, R140Q-IDH2, R172K-IDH2.
AGI-5198 induces demethylation of histone H3K9me3 and expression of genes associated with gliogenic differentiation, impairs the growth of IDH1-mutant glioma cells.
AGI-5198 decreases levels of D-2-HG in chondrosarcoma cell lines.
| M.Wt | 462.5591 | |
| Formula | C27H31FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
1H-Imidazole-1-acetamide, N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl- |
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1. Rohle D, et al. Science. 2013 May 3;340(6132):626-30.
2. Suijker J, et al. Oncotarget. 2015 May 20;6(14):12505-19.
3. Molenaar RJ, et al. Cancer Res. 2015 Nov 15;75(22):4790-802.
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