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Chemical Structure : AGN194310
CAS No.: 229961-45-9
Catalog No.: PC-20205Not For Human Use, Lab Use Only.
AGN194310 (VTP-194310) is a highly potent, pan-RAR antagonist with binding Kd value of 2-5 nM, inhibits prostate carcinoma lines LNCaP, PC3 and DU145 with IC50 of 16-34 nM.
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AGN194310 (VTP-194310) is a highly potent, pan-RAR antagonist with binding Kd value of 2-5 nM, inhibits prostate carcinoma lines LNCaP, PC3 and DU145 with IC50 of 16-34 nM.
AGN194310 treatment led to a transient accumulation of flask-cultured cells in G1 followed by apoptosis.
AGN194310 is 12-22 fold more potent than all-trans retinoic acid (ATRA) against cell lines and also more potent in inhibiting the growth of primary prostate carcinoma cells.
| M.Wt | 424.56 | |
| Formula | C28H24O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[2-[4-(4-Ethylphenyl)-2,2-dimethyl-2H-1-benzothiopyran-6-yl]ethynyl]benzoic acid |
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1. Hammond LA, et al. Br J Cancer. 2001 Aug 3;85(3):453-62.
2. Walkley CR, et al. Leukemia. 2002 Sep;16(9):1763-72.
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