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AH-23848 calcium salt

Chemical Structure : AH-23848 calcium salt

CAS No.: 81496-19-7

AH-23848 calcium salt (AH23848;AH 23848)

Catalog No.: PC-70016Not For Human Use, Lab Use Only.

A dual antagonist of TP1 and EP4 receptors that inhibit TXA2-induced platelet aggregation with IC50 of 0.26 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A dual antagonist of TP1 and EP4 receptors that inhibit TXA2-induced platelet aggregation with IC50 of 0.26 uM; impairs PGE2-mediated relaxation of piglet saphenous vein by antagonizing the PGE2 receptor EP4.

Physicochemical Properties

M.Wt 496.6
Formula C29H34NO5 • 1/2Ca
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-7-((1S,2S,5R)-5-([1,1'-biphenyl]-4-ylmethoxy)-3-oxo-2-(tetrahydro-2H-pyran-4-yl)cyclopentyl)hept-4-enoic acid

References

1. Brittain RT, et al. Circulation. 1985 Dec;72(6):1208-18.

2. Coker SJ, et al. Br J Pharmacol. 1985 Sep;86(1):259-64.

3. Qian X, et al. J Biol Chem. 2011 Jan 21;286(3):2111-20.

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