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Chemical Structure : AI-1
CAS No.: 75483-04-4
Catalog No.: PC-62429Not For Human Use, Lab Use Only.
Nrf2 activator AI-1 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1, activates an ARE-dependent luciferase reporter with an EC50 of 2.7 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $488 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Nrf2 activator AI-1 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1, activates an ARE-dependent luciferase reporter with an EC50 of 2.7 uM.
Nrf2 activator AI-1 is an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response.
| M.Wt | 265.69 | |
| Formula | C13H12ClNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate |
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1. Hur W, et al. Chem Biol. 2010 May 28;17(5):537-47.
2. Large M, et al. Strahlenther Onkol. 2015 Sep;191(9):742-9.
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