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Chemical Structure : AI-10-104
Catalog No.: PC-61299Not For Human Use, Lab Use Only.
AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays.
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AI-10-104 is a small molecule inhibitor that interferes with CBFβ binding to RUNX proteins with IC50 of 1.25 uM in FRET assays.
AI-10-104 reduces RUNX transcriptional activity by interfering with the formation of the CBFβ/RUNX1 and/or CBFβ/RUNX3 heterodimers in T-ALL cells.
AI-10-104 impairs the growth of human T-ALL cell lines and primary patient samples (GI50=2.4 uM).
| M.Wt | 309.248 | |
| Formula | C14H10F3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Choi A, et al. Blood. 2017 Oct 12;130(15):1722-1733.
2. Illendula A, et al. EBioMedicine. 2016 Jun;8:117-31.
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