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Chemical Structure : AI-2
Catalog No.: PC-62430Not For Human Use, Lab Use Only.
Nrf2 activator AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1.
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Nrf2 activator AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1.
AI-2 exhibits approximately 10-fold higher potency in Nrf2 activation and expression of NQO1 relative to AI-1.
AI-2 is an useful pharmacological probe for investigating the molecular details of the cellular antioxidant response.
| M.Wt | 342.779 | |
| Formula | C18H15ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hur W, et al. Chem Biol. 2010 May 28;17(5):537-47.
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