AJM347 | α4β7 integrin antagonist | Probechem Biochemicals

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Chemical Structure : AJM347

AJM347 (AJM-347)

Catalog No.: PC-27662Not For Human Use, Lab Use Only.

AJM347 is a potent, selective and orally active α4β7 integrin antagonist, inhibits the binding of immune cells expressing α4β7 integrin to gastrointestinal submucosa, while not interacting with cells expressing α4β1 integrin.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AJM347 is a potent, selective and orally active α4β7 integrin antagonist, inhibits the binding of immune cells expressing α4β7 integrin to gastrointestinal submucosa, while not interacting with cells expressing α4β1 integrin.

Physicochemical Properties

M.Wt	840.86
Formula	C41H38F2N8O8S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	isopropyl (S)-2-(2,5-difluoro-4-((4-(2-(tetrahydro-2H-pyran-4-yl)pyrimidin-5-yl)phenyl)sulfonamido)benzamido)-3-(6-(1-methyl-2,4-dioxo-1,4-dihydropyrido[3,4-d]pyrimidin-3(2H)-yl)pyridin-3-yl)propanoate

References

1. Koyama T, et al. J Clin Pharmacol. 2026 Aug;66(8):e70260.

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AJM347 (AJM-347)

Biological Activity

Physicochemical Properties

References

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