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AKU-005

Chemical Structure : AKU-005

CAS No.: 1515855-85-2

AKU-005 (AKU005)

Catalog No.: PC-20488Not For Human Use, Lab Use Only.

AKU-005 is a potent, dual MAGL/FAAH inhibitor with IC50 of 589 and 309 pM for MAGL in rat and mouse brain membrane respectively, inhibits rat and human FAAH with IC50 of 63 and 389 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AKU-005 is a potent, dual MAGL/FAAH inhibitor with IC50 of 589 and 309 pM for MAGL in rat and mouse brain membrane respectively, inhibits rat and human FAAH with IC50 of 63 and 389 nM.

Physicochemical Properties

M.Wt 347.42
Formula C20H21N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O=C(N1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)N4N=CN=C4

References

1. Niina Aaltonen, et al. Chem Biol. 2013 Mar 21;20(3):379-90.

2. Adriana Della Pietra, et al. J Headache Pain. 2023 Apr 11;24(1):38.

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