ALDH2 activator Z17

Chemical Structure : ALDH2 activator Z17

Catalog No.: PC-26320Not For Human Use, Lab Use Only.

ALDH2 activator Z17 is a small molecule aldehyde dehydrogenase 2 (ALDH2) activator with EC50 of 16.4 uM and ALDH2 maximum activation fold of 5.4.

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Biological Activity

ALDH2 activator Z17 is a small molecule aldehyde dehydrogenase 2 (ALDH2) activator with EC50 of 16.4 uM and ALDH2 maximum activation fold of 5.4.
Z17 exhibited significantly efficacy not only in enhancing cardiac function but also in mitigating myocardial necrosis on myocardial I/R injured mice.

Physicochemical Properties

M.Wt	430.86
Formula	C21H20ClFN4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, 2-chloro-6-(cyclopropylmethoxy)-N-[(3-fluoro-4-methoxyphenyl)methyl]-3-(4H-1,2,4-triazol-4-yl)-

References

1. Fengping Zhao, et al. ACS Med Chem Lett. 2025 Jun 9;16(7):1420-1427.

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