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ALI6

Chemical Structure : ALI6

CAS No.: 1841-19-6

ALI6 (Fluspirilene, Aβ-LilrB2 interaction inhibitor 6)

Catalog No.: PC-38408Not For Human Use, Lab Use Only.

ALI6 (Fluspirilene, Aβ-LilrB2 interaction inhibitor 6) is a small molecule Aβ-LilrB2 interaction inhibitor with Ki of 320 nM, blocks LilrB2 induced cell attachment and inhibit toxicity of Aβ.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ALI6 (Fluspirilene, Aβ-LilrB2 interaction inhibitor 6) is a small molecule Aβ-LilrB2 interaction inhibitor with Ki of 320 nM, blocks LilrB2 induced cell attachment and inhibit toxicity of Aβ.
ALI6 (Fluspirilene) inhibits the binding of Aß to neurons, protects neurons from Aß-induced changes in the cofilin signaling pathway. ALI6 (Fluspirilene) also is a diphenylbutylpiperidine typical antipsychotic drug, used for the treatment of schizophrenia.

Physicochemical Properties

M.Wt 475.57
Formula C29H31F2N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

References

1. Qin Cao, et al. Nat Chem. 2018 Dec;10(12):1213-1221.

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