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Chemical Structure : ALK5-IN-16i
Catalog No.: PC-61453Not For Human Use, Lab Use Only.
A potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3.
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A potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3; inhibits Smad2/3 phosphorylation in A549 cells (IC50=79 nM); significantly decreases Smad2 phosphorylation in mouse skin after topical application; may serves as a potential new therapy for AGA.
| M.Wt | 427.541 | |
| Formula | C20H21N5O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Amada H, et al. Bioorg Med Chem. 2012 Dec 15;20(24):7128-38.
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