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Chemical Structure : ALW-II-41-27
CAS No.: 1186206-79-0
Catalog No.: PC-45397Not For Human Use, Lab Use Only.
ALW-II-41-27 is an ATP-competitive EPHA2 RTK inhibitor with IC50 of 11 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $168 | In stock | |
| 25 mg | $288 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | $728 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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ALW-II-41-27 is an ATP-competitive EPHA2 RTK inhibitor with IC50 of 11 nM.
ALW-II-41-27 reduces the number of viable NSCLC cells in a time-dependent and dose-dependent manner in vitro and induces tumor regression in human NSCLC xenografts in vivo.
ALW-II-41-27 decreases both survival and proliferation of erlotinib-resistant tumor cells and inhibits tumor growth in vivo.
ALW-II-41-27 also decreasrd viability of cells with acquired resistance to the third-generation EGFR TKI AZD9291.
| M.Wt | 607.689 | |
| Formula | C32H32F3N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 47 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[[[5-(2-thienyl)-3-pyridinyl]carbonyl]amino]- |
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1. Choi Y, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.
2. Amato KR, et al. J Clin Invest. 2014 May;124(5):2037-49.
3. Amato KR, et al. Cancer Res. 2016 Jan 15;76(2):305-18.
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