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Chemical Structure : ALY688
Catalog No.: PC-73202Not For Human Use, Lab Use Only.
ALY688 (ADP 355) is an adiponectin mimetic adiponectin receptor (AdipoR) agonist, inhibits the growth of AdipoR1/AdipoR2-positive cancer cell lines (MCF-7 cell, 0.1-10 uM).
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ALY688 (ADP 355) is an adiponectin mimetic adiponectin receptor (AdipoR) agonist, inhibits the growth of AdipoR1/AdipoR2-positive cancer cell lines (MCF-7 cell, 0.1-10 uM).
ALY688 (ADP 355) differentially modulates AdipoR signaling pathways, increases the phosphorylation of AMPK, decreases ERK1/2 phosphorylation in MCF-7 cells.
ALY688 (ADP 355) inhibits the growth of MCF-7 xenografts in immunocompromised mice.
ALY688 (ADP 355) elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells.
ALY688 (ADP 355) promoted AMPK and acetyl-CoA carboxylase (ACC) phosphorylation, enhanced glucose oxidation, and suppressed fat oxidation in adipocytes from both fat depots.
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| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Laszlo Otvos Jr, et al. BMC Biotechnol. 2011 Oct 5;11:90.
2. Hye Kyoung Sung, et al. Am J Physiol Cell Physiol. 2022 Feb 1;322(2):C151-C163.
3. Da Eira D, et al. Adipocyte. 2020 Dec;9(1):550-562.
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