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Chemical Structure : AM-0902
CAS No.: 1883711-97-4
Catalog No.: PC-61124Not For Human Use, Lab Use Only.
AM-0902 (AMG0902) is a potent, selective, orally active TRPA1 channel antagonist with IC50 of 71 and 131 nM for rTRPA1 and hTRPA1 in Ca2+ flux assays respectively, without agonist activity (EC50>40 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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AM-0902 (AMG0902) is a potent, selective, orally active TRPA1 channel antagonist with IC50 of 71 and 131 nM for rTRPA1 and hTRPA1 in Ca2+ flux assays respectively, without agonist activity (EC50>40 uM).
AM-0902 (AMG0902) shows good selectivity over other TRP channels, including human TRPV1 and TRPV4, rat TRPV1, TRPV3, and TRPM8 (IC50>10 uM).
AM-0902 (AMG0902) demonstrates dose-dependent inhibition of AITC-induced flinching in rats.
| M.Wt | 370.797 | |
| Formula | C17H15ClN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-((3-(4-Chlorophenethyl)-1,2,4-oxadiazol-5-yl)methyl)-7-methyl-1H-purin-6(7H)-one |
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1. Schenkel LB, et al. J Med Chem. 2016 Mar 24;59(6):2794-809.
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