Chemical Structure : AM-2394
CAS No.: 1442684-77-6
Catalog No.: PC-42091Not For Human Use, Lab Use Only.
A potent, orally bioavailable Glucokinase (GK) activator with EC50 of 60 nM.
Packing | Price | Stock | Quantity |
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10 mg | $128 | In stock | |
50 mg | $440 | In stock | |
100 mg | $760 | In stock |
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AM-2394 is a potent, orally bioavailable Glucokinase (GK) activator with EC50 of 60 nM.
AM-2394 increases the affinity of GK for glucose by 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models.
AM-2394 lowers glucose excursion in an ob/ob mouse model of diabetes.
M.Wt | 423.465 | |
Formula | C22H25N5O4 | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: ≥ 30 mg/mL |
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Chemical Name/SMILES |
Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl- |
1. Kohn TJ, et al. ACS Med Chem Lett. 2016 Jun 1;7(7):666-70.
2. Dransfield PJ, et al. ACS Med Chem Lett. 2016 May 23;7(7):714-8.
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