AM-8719 (AM8719)

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Chemical Structure : AM-8719

Catalog No.: PC-27646Not For Human Use, Lab Use Only.

AM-8719 (AM8719) is a potent, selective, CNS-penetrant, orally efficacious KRAS G12C inhibitor with cellular activity (p-ERK, IC50=157 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AM-8719 (AM8719) is a potent, selective, CNS-penetrant, orally efficacious KRAS G12C inhibitor with cellular activity (p-ERK, IC50=157 nM).
AM-8719 (30 mg/kg, p.o.) induces robust decrease in p-ERK levels and tumor regression in a KRAS G12C tumor xenograft model (MIA PaCa-2 T2).

Physicochemical Properties

M.Wt	615.70
Formula	C31H40F3N7O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-((2R,3R)-1-(6-(4-(2-(3-Methoxyoxetan-3-yl)-4-Methylpyridin-3-yl)Piperidin-1-yl)-2-(Trifluoromethyl)Pyrimidin-4-yl)-2-Methylazetidin-3-yl)Piperazin-1-yl)Prop-2-en-1-one

References

1. Rast S, et al. J Med Chem. 2026 Aug 13;69(15):19050-19064.

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AM-8719 (AM8719)

Biological Activity

Physicochemical Properties

References

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