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Chemical Structure : AM095
CAS No.: 1345614-59-6
Catalog No.: PC-49650Not For Human Use, Lab Use Only.
AM095 (AM-095) is a potent, selective and orally active lysophosphatidic acid type 1 receptor (LPA1) antagonist with IC50 of 0.98 and 0.73 uM for hLPA1 and mLPA1 in GTP S binding assays, respectively, with no LPA1 agonism.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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AM095 (AM-095) is a potent, selective and orally active lysophosphatidic acid type 1 receptor (LPA1) antagonist with IC50 of 0.98 and 0.73 uM for hLPA1 and mLPA1 in GTP S binding assays, respectively, with no LPA1 agonism.
AM095 inhibited LPA-driven chemotaxis of CHO cells overexpressing mouse LPA1 (IC50=778 nM) and human A2058 melanoma cells (IC50=233 nM) in function assays.
AM095 inhibited LPA1-driven chemotaxis of both human A2058 melanoma cells (IC50 =0.23 uM) and mouse LPA1/CHO cells (IC50=0.78 uM)。
AM095 dose-dependently reduced LPA-stimulated histamine release, attenuated bleomycin-induced increases in collagen, protein, and inflammatory cell infiltration in bronchalveolar lavage fluid in vivo.
AM095 decreased kidney fibrosis in a mouse unilateral ureteral obstruction model.
| M.Wt | 478.48 | |
| Formula | C27H23N2NaO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
sodium, {4'-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-acetate |
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1. Swaney JS, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):693-700.
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